Positron Emission Tomography

PET Imaging

PET imaging and quantitative analysis of the binding of I-124-Annexin V to Phosphatidylserine in imaging apoptosis.

Positron Emission Tomography is a functional imaging modality that is characterized with a high degree of sensitivity because it utilizes the combination of the radiotracer principle and coincidence detection as a result of positron decay. It is therefore capable of directly viewing molecular targets and biological pathways in-vivo. It has, for example, the ability to image tissue perfusion, glucose metabolism, cell proliferation, drug and receptor interactions and gene expression, as well as other normal and pathophysiological functions in health and disease. The functional capability achieved with PET is now greatly enhanced with the combination of PET/CT, enabling accurate and high-resolution localization of radiolabeled molecules and cells with much greater anatomical detail.

The Center for Molecular Imaging has a GE Advance PET/CT for clinical translational research and an R4 MicroPET scanner for animal imaging. A new PET/SPECT/CT animal scanner will shortly be installed in the center.

 

Animal fpac

Multi-drug resistance is a major problem in cancer chemotherapy. The expression of the Pgp protein in tumors is an obstacle to drug delivery and retention within tumors. The images above illustrate uptake and no uptake of F-18-FDG and F-18-FPAC (a chemotherapeutic drug) in Pgp- and Pgp+ tumors, respectively.

 

Human FPAC

Patient FPAC